Media reports discussed Scott as a possible 2024 Republican vice presidential candidate. Former President Donald Trump (R) selected U.S. Sen. J.D. Vance (R-Ohio) as his running mate on July 15, 2024, the first day of the 2024 Republican National Convention. In 2020, President Joe Biden (D) announced Vice President Kamala Harris (D) as his running mate six days before the start of the Democratic National Convention (DNC). In 2016, both Hillary Clinton (D) and Trump announced their running mates three days before the DNC and RNC, respectively. Response to President Joe Biden’s (D) first address to joint session of Congress (2021) Scott delivered the Republican response to Joe Biden’s first address to a joint session of Congress on April 28, 2021. In response to Biden’s discussion of racial issues in his speech, Scott said, “America is not a racist country […] it's wrong to try to use our painful past to try to dishonestly shut down debates in the present." Scott also criticized Biden’s coronavirus response, saying it was partisan and resulted in the expansion of government. Scott said Biden’s actions were dividing the country despite his campaign promises to unite the nation. Just and Unifying Solutions to Invigorate Communities Everywhere (JUSTICE) Act (2020) Following the murder of George Floyd by Minneapolis police officer Derek Chauvin, Scott drafted the Just and Unifying Solutions to Invigorate Communities Everywhere (JUSTICE) Act. Scott’s bill proposed banning the use of chokeholds, increased body camera usage, and additional training and resources for police departments. The bill did not include restricting or ending the use of qualified immunity. It did not pass the Senate. After President Joe Biden (D) issued an executive order on law enforcement in May 2022, Scott said that Biden used many of the same reforms from the Justice Act. Scott said in a statement, "After the radical ‘defund the police’ movement helped create the current crime wave, President Biden is pursuing a partisan approach to many of the exact same policy solutions I proposed in the JUSTICE Act just two years ago. The fact is Democrats used a filibuster they call racist to block my reforms that they’re now embracing." Tax Cuts and Jobs Act (2017) Following the Unite the Right rally and counter-protests in Charlottesville, Virginia, in August of 2017, Scott met with President Donald Trump (R) to discuss the situation. In the meeting, Scott presented the idea of Opportunity Zones for investing in economically-distressed communities as a way to help minorities. Opportunity Zones are areas designated by the IRS as economically distressed and investments in these areas qualify for preferential tax treatment. The Opportunity Zones were included in the Tax Cuts and Jobs Act of 2017 with Scott’s assistance. Letter to Iran regarding nuclear agreement (2015) On March 9, 2015, Senator Tom Cotton (R-Ark.) wrote a letter to Iran's leadership, warning them that signing a nuclear deal with the Obama administration without congressional approval constituted only an executive agreement. The letter also stated that "The next president could revoke such an executive agreement with the stroke of a pen and future Congresses could modify the terms of the agreement at any time." The letter was signed by 47 Republican members of the Senate. Scott was one of the 47 who signed the letter. No Democrats signed it. Members of the Obama administration and of Congress reacted to the letter. Vice President Joe Biden said of the letter, "In thirty-six years in the United States Senate, I cannot recall another instance in which senators wrote directly to advise another country — much less a longtime foreign adversary — that the president does not have the constitutional authority to reach a meaningful understanding with them." Participation in Senator Rand Paul's (R) filibuster of CIA Director nominee John Brennan (2013) On March 6, 2013, Senator Rand Paul (R) led a 13-hour filibuster of President Obama's CIA Director nominee, John Brennan. Paul started the filibuster in order to highlight his concerns about the administration's drone policies. In particular, Paul said he was concerned about whether a drone could be used to kill an American citizen within the United States border without any due process involved. Paul and other civil liberties activists were critical of President Obama for not offering a clear response to the question. A total of 14 senators joined Paul in the filibuster—13 Republicans and one Democrat. Scott was one of the 13 Republican senators who joined Paul in his filibuster. Thirty Republican senators did not support the filibuster. The day after the filibuster, Attorney General Eric Holder sent a letter to Paul, responding to the filibuster. Holder wrote, "Does the president have the authority to use a weaponized drone to kill an American not engaged in combat on U.S. soil? The answer to that is no."

Media reports have discussed Scott as a possible Republican vice presidential candidate. Former President Donald Trump (R) became the presumptive Republican presidential nominee on March 12, 2024, and is expected to select a running mate ahead of the 2024 Republican National Convention (RNC), which will take place from July 15 to 18. In 2020, President Joe Biden (D) announced Vice President Kamala Harris (D) as his running mate six days before the start of the Democratic National Convention (DNC). In 2016, both Hillary Clinton (D) and Trump announced their running mates three days before the DNC and RNC, respectively. Response to President Joe Biden’s (D) first address to joint session of Congress (2021) Scott delivered the Republican response to Joe Biden’s first address to a joint session of Congress on April 28, 2021. In response to Biden’s discussion of racial issues in his speech, Scott said, “America is not a racist country […] it's wrong to try to use our painful past to try to dishonestly shut down debates in the present." Scott also criticized Biden’s coronavirus response, saying it was partisan and resulted in the expansion of government. Scott said Biden’s actions were dividing the country despite his campaign promises to unite the nation. Just and Unifying Solutions to Invigorate Communities Everywhere (JUSTICE) Act (2020) Following the murder of George Floyd by Minneapolis police officer Derek Chauvin, Scott drafted the Just and Unifying Solutions to Invigorate Communities Everywhere (JUSTICE) Act. Scott’s bill proposed banning the use of chokeholds, increased body camera usage, and additional training and resources for police departments. The bill did not include restricting or ending the use of qualified immunity. It did not pass the Senate. After President Joe Biden (D) issued an executive order on law enforcement in May 2022, Scott said that Biden used many of the same reforms from the Justice Act. Scott said in a statement, "After the radical ‘defund the police’ movement helped create the current crime wave, President Biden is pursuing a partisan approach to many of the exact same policy solutions I proposed in the JUSTICE Act just two years ago. The fact is Democrats used a filibuster they call racist to block my reforms that they’re now embracing." Tax Cuts and Jobs Act (2017) Following the Unite the Right rally and counter-protests in Charlottesville, Virginia, in August of 2017, Scott met with President Donald Trump (R) to discuss the situation. In the meeting, Scott presented the idea of Opportunity Zones for investing in economically-distressed communities as a way to help minorities. Opportunity Zones are areas designated by the IRS as economically distressed and investments in these areas qualify for preferential tax treatment. The Opportunity Zones were included in the Tax Cuts and Jobs Act of 2017 with Scott’s assistance. Letter to Iran regarding nuclear agreement (2015) On March 9, 2015, Senator Tom Cotton (R-Ark.) wrote a letter to Iran's leadership, warning them that signing a nuclear deal with the Obama administration without congressional approval constituted only an executive agreement. The letter also stated that "The next president could revoke such an executive agreement with the stroke of a pen and future Congresses could modify the terms of the agreement at any time." The letter was signed by 47 Republican members of the Senate. Scott was one of the 47 who signed the letter. No Democrats signed it. Members of the Obama administration and of Congress reacted to the letter. Vice President Joe Biden said of the letter, "In thirty-six years in the United States Senate, I cannot recall another instance in which senators wrote directly to advise another country — much less a longtime foreign adversary — that the president does not have the constitutional authority to reach a meaningful understanding with them." Participation in Senator Rand Paul's (R) filibuster of CIA Director nominee John Brennan (2013) On March 6, 2013, Senator Rand Paul (R) led a 13-hour filibuster of President Obama's CIA Director nominee, John Brennan. Paul started the filibuster in order to highlight his concerns about the administration's drone policies. In particular, Paul said he was concerned about whether a drone could be used to kill an American citizen within the United States border without any due process involved. Paul and other civil liberties activists were critical of President Obama for not offering a clear response to the question. A total of 14 senators joined Paul in the filibuster—13 Republicans and one Democrat. Scott was one of the 13 Republican senators who joined Paul in his filibuster. Thirty Republican senators did not support the filibuster. The day after the filibuster, Attorney General Eric Holder sent a letter to Paul, responding to the filibuster. Holder wrote, "Does the president have the authority to use a weaponized drone to kill an American not engaged in combat on U.S. soil? The answer to that is no."